Hilgo Bruining Selected Research

Bumetanide (Bumex)

1/2022	Bumetanide for Irritability in Children With Sensory Processing Problems Across Neurodevelopmental Disorders: A Pilot Randomized Controlled Trial.
1/2022	Single-case experimental designs for bumetanide across neurodevelopmental disorders: BUDDI protocol.
1/2022	Bumetanide Effects on Resting-State EEG in Tuberous Sclerosis Complex in Relation to Clinical Outcome: An Open-Label Study.
9/2021	Prediction of Behavioral Improvement Through Resting-State Electroencephalography and Clinical Severity in a Randomized Controlled Trial Testing Bumetanide in Autism Spectrum Disorder.
1/2021	Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): A Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase-2 Superiority Trial.
1/2021	Dr. Sprengers et al. Reply.
1/2020	Effects of bumetanide on neurodevelopmental impairments in patients with tuberous sclerosis complex: an open-label pilot study.
1/2017	Bumetanide As a Candidate Treatment for Behavioral Problems in Tuberous Sclerosis Complex.
8/2015	Paradoxical Benzodiazepine Response: A Rationale for Bumetanide in Neurodevelopmental Disorders?

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Hilgo Bruining Research Topics

Disease

7	Autism Spectrum Disorder 09/2021 - 05/2010
6	Neurodevelopmental Disorders 01/2022 - 08/2015
4	Tuberous Sclerosis (Bourneville's Disease) 01/2022 - 02/2014
4	Autistic Disorder (Autism) 09/2021 - 02/2014
3	Epilepsy (Aura) 01/2018 - 08/2015
2	Seizures (Absence Seizure) 01/2022 - 01/2017
1	Infantile Spasms (West Syndrome) 01/2022
1	Wounds and Injuries (Trauma) 01/2022
1	Rare Diseases (Rare Disease) 01/2022
1	Orthostatic Hypotension (Postural Hypotension) 01/2021
1	Hypokalemia 01/2021
1	Brain Diseases (Brain Disorder) 01/2018
1	Schizophrenia (Dementia Praecox) 01/2018
1	Stroke (Strokes) 01/2018
1	Mental Disorders (Mental Disorder) 01/2018
1	Delirium 01/2018
1	Temporal Lobe Epilepsy 08/2015
1	Malformations of Cortical Development 08/2015
1	Klinefelter Syndrome (Klinefelter's Syndrome) 02/2014
1	Inborn Genetic Diseases (Disease, Hereditary) 02/2014
1	Down Syndrome (Down's Syndrome) 02/2014

Drug/Important Bio-Agent (IBA)

9	Bumetanide (Bumex)FDA LinkGeneric 01/2022 - 08/2015
7	ChloridesIBA 01/2022 - 08/2015
4	gamma-Aminobutyric Acid (GABA)IBA 01/2021 - 08/2015
3	trans-sodium crocetinate (crocetin)IBA 01/2022 - 01/2017
3	Biomarkers (Surrogate Marker)IBA 09/2021 - 01/2021
2	DiureticsIBA 01/2021 - 08/2015
2	Aminobutyrates (Aminobutyric Acid)IBA 01/2021 - 08/2015
2	BenzodiazepinesIBA 01/2018 - 08/2015
1	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2022
1	oxynide (DS 6)IBA 01/2022
1	ChromatinIBA 01/2022
1	Pharmaceutical PreparationsIBA 01/2022
1	Phenobarbital (Luminal)FDA Link 01/2022
1	Proteins (Proteins, Gene)FDA Link 01/2022
1	SymportersIBA 01/2018
1	Anticonvulsants (Antiepileptic Drugs)IBA 03/2017
1	Clobazam (HR 376)IBA 08/2015
1	Fatty Acids (Saturated Fatty Acids)IBA 09/2014
1	Genetic Markers (Genetic Marker)IBA 02/2014
1	A-factor (Streptomyces)IBA 05/2010

Therapy/Procedure

1	Therapeutics 01/2022
1	Ketogenic Diet 01/2022